NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis

NF-κB-inducing kinase (NIK) is well-known for its role in promoting p100/NF-κB2 processing into p52, a process defined as the alternative, or non-canonical, NF-κB pathway. Here we reveal an unexpected new role of NIK in TNFR1-mediated RIP1-dependent apoptosis, a consequence of TNFR1 activation obser...

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Publicat a:Cell Death Differ
Autors principals: Boutaffala, L, Bertrand, M J M, Remouchamps, C, Seleznik, G, Reisinger, F, Janas, M, Bénézech, C, Fernandes, M T, Marchetti, S, Mair, F, Ganeff, C, Hupalowska, A, Ricci, J-E, Becher, B, Piette, J, Knolle, P, Caamano, J, Vandenabeele, P, Heikenwalder, M, Dejardin, E
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
Matèries:
Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816116/
https://ncbi.nlm.nih.gov/pubmed/26045047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.69
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