Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG-positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression

BACKGROUND: There is an acute need to uncover biomarkers that reflect the molecular pathologies, underpinning prostate cancer progression and poor patient outcome. We have previously demonstrated that in prostate cancer cell lines PDE4D7 is downregulated in advanced cases of the disease. To investig...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Böttcher, R, Henderson, D J P, Dulla, K, van Strijp, D, Waanders, L F, Tevz, G, Lehman, M L, Merkle, D, van Leenders, G J L H, Baillie, G S, Jenster, G, Houslay, M D, Hoffmann, R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815894/
https://ncbi.nlm.nih.gov/pubmed/26575822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.335
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