The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells

BACKGROUND: Isoforms of the PDE4 family of cAMP-specific phosphodiesterases (PDEs) are expressed in a cell type-dependent manner and contribute to underpinning the paradigm of intracellular cAMP signal compartmentalisation. Here we identify the differential regulation of the PDE4D7 isoform during pr...

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Detalhes bibliográficos
Main Authors: Henderson, D J P, Byrne, A, Dulla, K, Jenster, G, Hoffmann, R, Baillie, G S, Houslay, M D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950871/
https://ncbi.nlm.nih.gov/pubmed/24518597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.22
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