CYP24A1 variant modifies the association between use of oestrogen plus progestogen therapy and colorectal cancer risk

BACKGROUND: Menopausal hormone therapy (MHT) use has been consistently associated with a decreased risk of colorectal cancer (CRC) in women. Our aim was to use a genome-wide gene–environment interaction analysis to identify genetic modifiers of CRC risk associated with use of MHT. METHODS: We includ...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Br J Cancer
Prif Awduron: Garcia-Albeniz, Xabier, Rudolph, Anja, Hutter, Carolyn, White, Emily, Lin, Yi, Rosse, Stephanie A, Figueiredo, Jane C, Harrison, Tabitha A, Jiao, Shuo, Brenner, Hermann, Casey, Graham, Hudson, Thomas J, Thornquist, Mark, Le Marchand, Loic, Potter, John, Slattery, Martha L, Zanke, Brent, Baron, John A, Caan, Bette J, Chanock, Stephen J, Berndt, Sonja I, Stelling, Deanna, Fuchs, Charles S, Hoffmeister, Michael, Butterbach, Katja, Du, Mengmeng, James Gauderman, W, Gunter, Marc J, Lemire, Mathieu, Ogino, Shuji, Lin, Jennifer, Hayes, Richard B, Haile, Robert W, Schoen, Robert E, Warnick, Greg S, Jenkins, Mark A, Thibodeau, Stephen N, Schumacher, Fredrick R, Lindor, Noralane M, Kolonel, Laurence N, Hopper, John L, Gong, Jian, Seminara, Daniela, Pflugeisen, Bethann M, Ulrich, Cornelia M, Qu, Conghui, Duggan, David, Cotterchio, Michelle, Campbell, Peter T, Carlson, Christopher S, Newcomb, Polly A, Giovannucci, Edward, Hsu, Li, Chan, Andrew T, Peters, Ulrike, Chang-Claude, Jenny
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Genetics & Genomics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815813/
https://ncbi.nlm.nih.gov/pubmed/26766742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.443
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