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Analog sensitive chemical inhibition of the DEAD‐box protein DDX3

Proper maintenance of RNA structure and dynamics is essential to maintain cellular health. Multiple families of RNA chaperones exist in cells to modulate RNA structure, RNA–protein complexes, and RNA granules. The largest of these families is the DEAD‐box proteins, named after their catalytic Asp‐Gl...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Protein Sci
Autori principali: Floor, Stephen N., Barkovich, Krister J., Condon, Kendall J., Shokat, Kevan M., Doudna, Jennifer A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2015
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815421/
https://ncbi.nlm.nih.gov/pubmed/26650549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2857
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