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Analog sensitive chemical inhibition of the DEAD‐box protein DDX3

Proper maintenance of RNA structure and dynamics is essential to maintain cellular health. Multiple families of RNA chaperones exist in cells to modulate RNA structure, RNA–protein complexes, and RNA granules. The largest of these families is the DEAD‐box proteins, named after their catalytic Asp‐Gl...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Floor, Stephen N., Barkovich, Krister J., Condon, Kendall J., Shokat, Kevan M., Doudna, Jennifer A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815421/
https://ncbi.nlm.nih.gov/pubmed/26650549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2857
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