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Elucidating nitric oxide synthase domain interactions by molecular dynamics

Nitric oxide synthase (NOS) is a multidomain enzyme that catalyzes the production of nitric oxide (NO) by oxidizing l‐Arg to NO and L‐citrulline. NO production requires multiple interdomain electron transfer steps between the flavin mononucleotide (FMN) and heme domain. Specifically, NADPH‐derived e...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Hollingsworth, Scott A., Holden, Jeffrey K., Li, Huiying, Poulos, Thomas L.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815339/
https://ncbi.nlm.nih.gov/pubmed/26448477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2824
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