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The loss of inhibitory C‐terminal conformations in disease associated P123H β‐synuclein
β‐synuclein (βS) is a homologue of α‐synuclein (αS), the major protein component of Lewy bodies in patients with Parkinson's disease. In contrast to αS, βS does not form fibrils, mitigates αS toxicity in vivo and inhibits αS fibril formation in vitro. Previously a missense mutation of βS, P123H...
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| Veröffentlicht in: | Protein Sci |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4815300/ https://ncbi.nlm.nih.gov/pubmed/26332674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2798 |
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