Acetylation of C/EBPα inhibits its granulopoietic function

CCAAT/enhancer-binding protein alpha (C/EBPα) is an essential transcription factor for myeloid lineage commitment. Here we demonstrate that acetylation of C/EBPα at lysine residues K298 and K302, mediated at least in part by general control non-derepressible 5 (GCN5), impairs C/EBPα DNA-binding abil...

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Vydáno v:Nat Commun
Hlavní autoři: Bararia, Deepak, Kwok, Hui Si, Welner, Robert S., Numata, Akihiko, Sárosi, Menyhárt B., Yang, Henry, Wee, Sheena, Tschuri, Sebastian, Ray, Debleena, Weigert, Oliver, Levantini, Elena, Ebralidze, Alexander K., Gunaratne, Jayantha, Tenen, Daniel G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814574/
https://ncbi.nlm.nih.gov/pubmed/27005833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10968
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