Experimental and Metabolic Modeling Evidence for a Folate-Cleaving Side-Activity of Ketopantoate Hydroxymethyltransferase (PanB)

Tetrahydrofolate (THF) and its one-carbon derivatives, collectively termed folates, are essential cofactors, but are inherently unstable. While it is clear that chemical oxidation can cleave folates or damage their pterin precursors, very little is known about enzymatic damage to these molecules or...

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Bibliographic Details
Published in:Front Microbiol
Main Authors: Thiaville, Jennifer J., Frelin, Océane, García-Salinas, Carolina, Harrison, Katherine, Hasnain, Ghulam, Horenstein, Nicole A., Díaz de la Garza, Rocio I., Henry, Christopher S., Hanson, Andrew D., de Crécy-Lagard, Valérie
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2016
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814558/
https://ncbi.nlm.nih.gov/pubmed/27065985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2016.00431
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