Experimental and Metabolic Modeling Evidence for a Folate-Cleaving Side-Activity of Ketopantoate Hydroxymethyltransferase (PanB)

Tetrahydrofolate (THF) and its one-carbon derivatives, collectively termed folates, are essential cofactors, but are inherently unstable. While it is clear that chemical oxidation can cleave folates or damage their pterin precursors, very little is known about enzymatic damage to these molecules or...

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Bibliographische Detailangaben
Veröffentlicht in:Front Microbiol
Hauptverfasser: Thiaville, Jennifer J., Frelin, Océane, García-Salinas, Carolina, Harrison, Katherine, Hasnain, Ghulam, Horenstein, Nicole A., Díaz de la Garza, Rocio I., Henry, Christopher S., Hanson, Andrew D., de Crécy-Lagard, Valérie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2016
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814558/
https://ncbi.nlm.nih.gov/pubmed/27065985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2016.00431
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