Experimental and Metabolic Modeling Evidence for a Folate-Cleaving Side-Activity of Ketopantoate Hydroxymethyltransferase (PanB)

Tetrahydrofolate (THF) and its one-carbon derivatives, collectively termed folates, are essential cofactors, but are inherently unstable. While it is clear that chemical oxidation can cleave folates or damage their pterin precursors, very little is known about enzymatic damage to these molecules or...

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Detalles Bibliográficos
Publicado en:Front Microbiol
Main Authors: Thiaville, Jennifer J., Frelin, Océane, García-Salinas, Carolina, Harrison, Katherine, Hasnain, Ghulam, Horenstein, Nicole A., Díaz de la Garza, Rocio I., Henry, Christopher S., Hanson, Andrew D., de Crécy-Lagard, Valérie
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2016
Assuntos:
Microbiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814558/
https://ncbi.nlm.nih.gov/pubmed/27065985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2016.00431
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