Enhanced Uterine Contractility and Stillbirth in Mice Lacking G Protein-Coupled Receptor Kinase 6 (GRK6): Implications for Oxytocin Receptor Desensitization

Oxytocin is a potent uterotonic agent and is used clinically for induction and augmentation of labor, as well as for prevention and treatment of postpartum hemorrhage. Oxytocin increases uterine contractility by activating the oxytocin receptor (OXTR), a member of the G protein-coupled receptor fami...

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Detalhes bibliográficos
Publicado no:Mol Endocrinol
Main Authors: Grotegut, Chad A., Mao, Lan, Pierce, Stephanie L., Swamy, Geeta K., Heine, R. Phillips, Murtha, Amy P.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814475/
https://ncbi.nlm.nih.gov/pubmed/26886170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2015-1147
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