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Binomial mixture model-based association testing to account for genetic heterogeneity for GWAS

Genome-wide association studies (GWASs) have confirmed the ubiquitous existence of genetic heterogeneity for common disease: multiple common genetic variants have been identified to be associated, while many more are yet expected to be uncovered. On the other hand, the single SNP-based trend test (o...

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Pubblicato in:Genet Epidemiol
Autori principali: Xu, Zhiyuan, Pan, Wei
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814320/
https://ncbi.nlm.nih.gov/pubmed/26916514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.21954
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