Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects

Omenn syndrome (OS) is caused by hypomorphic Rag mutations and characterized by a profound immunodeficiency associated with autoimmune-like manifestations. Both in humans and mice, OS is mediated by oligoclonal activated T and B cells. The role of microbial signals in disease pathogenesis is debated...

詳細記述

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書誌詳細
出版年:J Exp Med
主要な著者: Rigoni, Rosita, Fontana, Elena, Guglielmetti, Simone, Fosso, Bruno, D’Erchia, Anna Maria, Maina, Virginia, Taverniti, Valentina, Castiello, Maria Carmina, Mantero, Stefano, Pacchiana, Giovanni, Musio, Silvia, Pedotti, Rosetta, Selmi, Carlo, Mora, J. Rodrigo, Pesole, Graziano, Vezzoni, Paolo, Poliani, Pietro Luigi, Grassi, Fabio, Villa, Anna, Cassani, Barbara
フォーマット: Artigo
言語:Inglês
出版事項: The Rockefeller University Press 2016
主題:
Research Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813669/
https://ncbi.nlm.nih.gov/pubmed/26926994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151116
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