Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects

Omenn syndrome (OS) is caused by hypomorphic Rag mutations and characterized by a profound immunodeficiency associated with autoimmune-like manifestations. Both in humans and mice, OS is mediated by oligoclonal activated T and B cells. The role of microbial signals in disease pathogenesis is debated...

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Detalles Bibliográficos
Publicado en:J Exp Med
Main Authors: Rigoni, Rosita, Fontana, Elena, Guglielmetti, Simone, Fosso, Bruno, D’Erchia, Anna Maria, Maina, Virginia, Taverniti, Valentina, Castiello, Maria Carmina, Mantero, Stefano, Pacchiana, Giovanni, Musio, Silvia, Pedotti, Rosetta, Selmi, Carlo, Mora, J. Rodrigo, Pesole, Graziano, Vezzoni, Paolo, Poliani, Pietro Luigi, Grassi, Fabio, Villa, Anna, Cassani, Barbara
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813669/
https://ncbi.nlm.nih.gov/pubmed/26926994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151116
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