Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell Function

The transcription factor, X-box-binding protein-1 (XBP1), controls the development and maintenance of the endoplasmic reticulum (ER) in multiple secretory cell lineages. We show here that Hepatocyte Nuclear Factor 4α (HNF4α) directly induces XBP1 expression. Mutations in HNF4α cause Mature-Onset Dia...

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Vydáno v:J Biol Chem
Hlavní autoři: Moore, Benjamin D., Jin, Ramon U., Lo, Heiyong, Jung, Min, Wang, Haiyan, Battle, Michele A., Wollheim, Claes B., Urano, Fumihiko, Mills, Jason C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813565/
https://ncbi.nlm.nih.gov/pubmed/26792861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.685750
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