Crystallization of hepatocyte nuclear factor 4α (HNF4α) in complex with the HNF1α promoter element

Hepatocyte nuclear factor 4α (HNF4α) is a member of the nuclear receptor superfamily that plays a central role in organ development and metabolic functions. Mutations on HNF4α cause maturity-onset diabetes of the young (MODY), a dominant monogenic cause of diabetes. In order to understand the molecu...

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Main Authors: Lu, Peng, Liu, Jianguo, Melikishvili, Manana, Fried, Michael G., Chi, Young-In
Format: Artigo
Jezik:Inglês
Izdano: International Union of Crystallography 2008
Teme:
Crystallization Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374247/
https://ncbi.nlm.nih.gov/pubmed/18391435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309108007136
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