Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1

P-Rex1 is a guanine-nucleotide exchange factor (GEF) that activates the small G protein (GTPase) Rac1 to control Rac1-dependent cytoskeletal dynamics, and thus cell morphology. Three mechanisms of P-Rex1 regulation are currently known: (i) binding of the phosphoinositide second messenger PIP(3), (ii...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Pan, Dingxin, Barber, Mark A., Hornigold, Kirsti, Baker, Martin J., Toth, Judit M., Oxley, David, Welch, Heidi C. E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813545/
https://ncbi.nlm.nih.gov/pubmed/26792863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.686592
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