Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization

Although trace levels of phosphorylated α-synuclein (α-syn) are detectable in normal brains, nearly all α-syn accumulated within Lewy bodies in Parkinson disease brains is phosphorylated on serine 129 (Ser-129). The role of the phosphoserine residue and its effects on α-syn structure, function, and...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Samuel, Filsy, Flavin, William P., Iqbal, Sobia, Pacelli, Consiglia, Sri Renganathan, Sri Dushyaanthan, Trudeau, Louis-Eric, Campbell, Edward M., Fraser, Paul E., Tandon, Anurag
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2016
Onderwerpen:
Molecular Bases of Disease
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813466/
https://ncbi.nlm.nih.gov/pubmed/26719332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.705095
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