Effect of Ser-129 Phosphorylation on Interaction of α-Synuclein with Synaptic and Cellular Membranes

In the healthy brain, less than 5% of α-synuclein (α-syn) is phosphorylated at serine 129 (Ser(P)-129). However, within Parkinson disease (PD) Lewy bodies, 89% of α-syn is Ser(P)-129. The effects of Ser(P)-129 modification on α-syn distribution and solubility are poorly understood. As α-syn normally...

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Bibliografiske detaljer
Main Authors: Visanji, Naomi P., Wislet-Gendebien, Sabine, Oschipok, Loren W., Zhang, Gang, Aubert, Isabelle, Fraser, Paul E., Tandon, Anurag
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195582/
https://ncbi.nlm.nih.gov/pubmed/21849493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.253450
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