α-Synuclein Membrane Association Is Regulated by the Rab3a Recycling Machinery and Presynaptic Activity

α-Synuclein is an abundant presynaptic protein and a primary component of Lewy bodies in Parkinson disease. Although its pathogenic role remains unclear, in healthy nerve terminals α-synuclein undergoes a cycle of membrane binding and dissociation. An α-synuclein binding assay was used to screen for...

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Autori principali: Chen, Robert H. C., Wislet-Gendebien, Sabine, Samuel, Filsy, Visanji, Naomi P., Zhang, Gang, Marsilio, Diana, Langman, Tammy, Fraser, Paul E., Tandon, Anurag
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597785/
https://ncbi.nlm.nih.gov/pubmed/23344955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.439497
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