High avidity chimeric monoclonal antibodies against the extracellular domains of human aquaporin‐4 competing with the neuromyelitis optica autoantibody, NMO‐IgG

BACKGROUND AND PURPOSE: Most of the cases of neuromyelitis optica (NMO) are characterized by the presence of an autoantibody, NMO‐IgG, which recognizes the extracellular domains of the water channel, aquaporin‐4. Binding of NMO‐IgG to aquaporin‐4 expressed in end‐feet of astrocytes leads to compleme...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Miyazaki‐Komine, Kaori, Takai, Yoshiki, Huang, Ping, Kusano‐Arai, Osamu, Iwanari, Hiroko, Misu, Tatsuro, Koda, Katsushi, Mitomo, Katsuyuki, Sakihama, Toshiko, Toyama, Yoshiaki, Fujihara, Kazuo, Hamakubo, Takao, Yasui, Masato, Abe, Yoichiro
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813391/
https://ncbi.nlm.nih.gov/pubmed/26398585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13340
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