High avidity chimeric monoclonal antibodies against the extracellular domains of human aquaporin‐4 competing with the neuromyelitis optica autoantibody, NMO‐IgG

BACKGROUND AND PURPOSE: Most of the cases of neuromyelitis optica (NMO) are characterized by the presence of an autoantibody, NMO‐IgG, which recognizes the extracellular domains of the water channel, aquaporin‐4. Binding of NMO‐IgG to aquaporin‐4 expressed in end‐feet of astrocytes leads to compleme...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Miyazaki‐Komine, Kaori, Takai, Yoshiki, Huang, Ping, Kusano‐Arai, Osamu, Iwanari, Hiroko, Misu, Tatsuro, Koda, Katsushi, Mitomo, Katsuyuki, Sakihama, Toshiko, Toyama, Yoshiaki, Fujihara, Kazuo, Hamakubo, Takao, Yasui, Masato, Abe, Yoichiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2015
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813391/
https://ncbi.nlm.nih.gov/pubmed/26398585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13340
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