Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody

INTRODUCTION: Neuromyelitis optica (NMO), an autoimmune astrocytopathic disease associated with anti-aquaporin-4 (AQP4) antibody, is characterized by extensive necrotic lesions preferentially involving the optic nerves and spinal cord. However, previous in-vivo experimental models injecting human an...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol Commun
Main Authors: Kurosawa, Kazuhiro, Misu, Tatsuro, Takai, Yoshiki, Sato, Douglas Kazutoshi, Takahashi, Toshiyuki, Abe, Yoichiro, Iwanari, Hiroko, Ogawa, Ryo, Nakashima, Ichiro, Fujihara, Kazuo, Hamakubo, Takao, Yasui, Masato, Aoki, Masashi
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670539/
https://ncbi.nlm.nih.gov/pubmed/26637322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0259-2
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