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Phosphorylation and calcium antagonistically tune myosin-binding protein C’s structure and function
During each heartbeat, cardiac contractility results from calcium-activated sliding of actin thin filaments toward the centers of myosin thick filaments to shorten cellular length. Cardiac myosin-binding protein C (cMyBP-C) is a component of the thick filament that appears to tune these mechanochemi...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4812749/ https://ncbi.nlm.nih.gov/pubmed/26908872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522236113 |
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