Phosphorylation and calcium antagonistically tune myosin-binding protein C’s structure and function

During each heartbeat, cardiac contractility results from calcium-activated sliding of actin thin filaments toward the centers of myosin thick filaments to shorten cellular length. Cardiac myosin-binding protein C (cMyBP-C) is a component of the thick filament that appears to tune these mechanochemi...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Previs, Michael J., Mun, Ji Young, Michalek, Arthur J., Previs, Samantha Beck, Gulick, James, Robbins, Jeffrey, Warshaw, David M., Craig, Roger
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4812749/
https://ncbi.nlm.nih.gov/pubmed/26908872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522236113
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