Autoantibody-boosted T-cell reactivation in the target organ triggers manifestation of autoimmune CNS disease

Multiple sclerosis (MS) is caused by T cells that are reactive for brain antigens. In experimental autoimmune encephalomyelitis, the animal model for MS, myelin-reactive T cells initiate the autoimmune process when entering the nervous tissue and become reactivated upon local encounter of their cogn...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Flach, Anne-Christine, Litke, Tanja, Strauss, Judith, Haberl, Michael, Gómez, César Cordero, Reindl, Markus, Saiz, Albert, Fehling, Hans-Jörg, Wienands, Jürgen, Odoardi, Francesca, Lühder, Fred, Flügel, Alexander
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4812745/
https://ncbi.nlm.nih.gov/pubmed/26957602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519608113
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