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Dynamic control of strand excision during human DNA mismatch repair

Mismatch repair (MMR) is activated by evolutionarily conserved MutS homologs (MSH) and MutL homologs (MLH/PMS). MSH recognizes mismatched nucleotides and form extremely stable sliding clamps that may be bound by MLH/PMS to ultimately authorize strand-specific excision starting at a distant 3′- or 5′...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Jeon, Yongmoon, Kim, Daehyung, Martín-López, Juana V., Lee, Ryanggeun, Oh, Jungsic, Hanne, Jeungphill, Fishel, Richard, Lee, Jong-Bong
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4812718/
https://ncbi.nlm.nih.gov/pubmed/26951673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523748113
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