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Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium

Individual signaling pathways are not isolated, but rather operate in the context of the broader signaling network. Thus, the response of a cell to perturbation of a given pathway depends on the state of the network, which depends upon contextual inputs from the microenvironment. The cytokine tumor...

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Dettagli Bibliografici
Pubblicato in:Sci Signal
Autori principali: Gierut, Jessica J., Wood, Levi B., Lau, Ken S., Lin, Yi-Jang, Genetti, Casie, Samatar, Ahmed A., Lauffenburger, Douglas A., Haigis, Kevin M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4812576/
https://ncbi.nlm.nih.gov/pubmed/26671150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aac7235
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