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Oncogenic K-Ras Promotes Proliferation in Quiescent Intestinal Stem Cells
K-Ras is a monomeric GTPase that controls cellular and tissue homeostasis. Prior studies demonstrated that mutationally activated K-Ras (K-Ras(G12D)) signals through MEK to promote expansion and hyperproliferation of the highly mitotically active transit-amplifying cells (TACs) in the intestinal cry...
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| Publicado no: | Stem Cell Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4629819/ https://ncbi.nlm.nih.gov/pubmed/26079371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2015.06.003 |
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