Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes

Embryonal Rhabdomyosarcoma (ERMS) and Undifferentiated Pleomorphic Sarcoma (UPS) are distinct sarcoma subtypes. Here we investigate the relevance of the satellite cell (SC) niche in sarcoma development by using Hepatocyte Growth Factor (HGF) to perturb the niche microenvironment. In a Pax7 wild type...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Morena, Deborah, Maestro, Nicola, Bersani, Francesca, Forni, Paolo Emanuele, Lingua, Marcello Francesco, Foglizzo, Valentina, Šćepanović, Petar, Miretti, Silvia, Morotti, Alessandro, Shern, Jack F, Khan, Javed, Ala, Ugo, Provero, Paolo, Sala, Valentina, Crepaldi, Tiziana, Gasparini, Patrizia, Casanova, Michela, Ferrari, Andrea, Sozzi, Gabriella, Chiarle, Roberto, Ponzetto, Carola, Taulli, Riccardo
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2016
Teme:
Cell Biology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811764/
https://ncbi.nlm.nih.gov/pubmed/26987019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12116
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