Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes

Embryonal Rhabdomyosarcoma (ERMS) and Undifferentiated Pleomorphic Sarcoma (UPS) are distinct sarcoma subtypes. Here we investigate the relevance of the satellite cell (SC) niche in sarcoma development by using Hepatocyte Growth Factor (HGF) to perturb the niche microenvironment. In a Pax7 wild type...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Morena, Deborah, Maestro, Nicola, Bersani, Francesca, Forni, Paolo Emanuele, Lingua, Marcello Francesco, Foglizzo, Valentina, Šćepanović, Petar, Miretti, Silvia, Morotti, Alessandro, Shern, Jack F, Khan, Javed, Ala, Ugo, Provero, Paolo, Sala, Valentina, Crepaldi, Tiziana, Gasparini, Patrizia, Casanova, Michela, Ferrari, Andrea, Sozzi, Gabriella, Chiarle, Roberto, Ponzetto, Carola, Taulli, Riccardo
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811764/
https://ncbi.nlm.nih.gov/pubmed/26987019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12116
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