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Structural Basis for Iron-mediated Sulfur Transfer in Archael and Yeast Thiazole Synthases

Thiamin diphosphate is an essential cofactor in all forms of life and plays a key role in amino acid and carbohydrate metabolism. Its biosynthesis involves separate syntheses of the pyrimidine and thiazole moieties, which are then coupled to form thiamin monophosphate. A final phosphorylation produc...

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Détails bibliographiques
Publié dans:Biochemistry
Auteurs principaux: Zhang, Xuan, Eser, Bekir E., Chanani, Prem K., Begley, Tadhg P., Ealick, Steven E.
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811699/
https://ncbi.nlm.nih.gov/pubmed/26919468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00030
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