Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells

Differentiated macrophages can self-renew in tissues and expand long-term in culture, but the gene regulatory mechanisms that accomplish self-renewal in the differentiated state have remained unknown. Here we show that in mice, the transcription factors MafB and c-Maf repress a macrophage-specific e...

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Vydáno v:Science
Hlavní autoři: Soucie, Erinn L., Weng, Ziming, Geirsdóttir, Laufey, Molawi, Kaaweh, Maurizio, Julien, Fenouil, Romain, Mossadegh-Keller, Noushine, Gimenez, Gregory, VanHille, Laurent, Beniazza, Meryam, Favret, Jeremy, Berruyer, Carole, Perrin, Pierre, Hacohen, Nir, Andrau, J.-C., Ferrier, Pierre, Dubreuil, Patrice, Sidow, Arend, Sieweke, Michael H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811353/
https://ncbi.nlm.nih.gov/pubmed/26797145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad5510
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