Structural basis for the recruitment of the human CCR4–NOT deadenylase complex by Tristetraprolin

Tristetraprolin (TTP) is an RNA binding protein that controls the inflammatory response by limiting the expression of several proinflammatory cytokines. TTP post-transcriptionally represses gene expression by interacting with AU-rich elements (AREs) in 3′UTRs of target mRNAs and subsequently engende...

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Pubblicato in:Nat Struct Mol Biol
Autori principali: Fabian, Marc R., Frank, Filipp, Rouya, Christopher, Siddiqui, Nadeem, Lai, Wi S., Karetnikov, Alexey, Blackshear, Perry J., Nagar, Bhushan, Sonenberg, Nahum
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811204/
https://ncbi.nlm.nih.gov/pubmed/23644599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2572
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