Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects

Planar cell polarity (PCP) is controlled by a conserved pathway that regulates directional cell behavior. Here, we show that mutant mice harboring a newly described mutation termed Beetlejuice (Bj) in Prickle1 (Pk1), a PCP component, exhibit developmental phenotypes involving cell polarity defects,...

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Bibliographic Details
Published in:Biol Open
Main Authors: Gibbs, Brian C., Damerla, Rama Rao, Vladar, Eszter K., Chatterjee, Bishwanath, Wan, Yong, Liu, Xiaoqin, Cui, Cheng, Gabriel, George C., Zahid, Maliha, Yagi, Hisato, Szabo-Rogers, Heather L., Suyama, Kaye L., Axelrod, Jeffrey D., Lo, Cecilia W.
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810743/
https://ncbi.nlm.nih.gov/pubmed/26883626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.015750
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