Comparative Mutagenesis of Pseudorabies Virus and Epstein-Barr Virus gH Identifies a Structural Determinant within Domain III of gH Required for Surface Expression and Entry Function

Herpesviruses infect cells using the conserved core fusion machinery composed of glycoprotein B (gB) and gH/gL. The gH/gL complex plays an essential but still poorly characterized role in membrane fusion and cell tropism. Our previous studies demonstrated that the conserved disulfide bond (DB) C278/...

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Publicado en:J Virol
Autores principales: Möhl, Britta S., Schröter, Christina, Klupp, Barbara G., Fuchs, Walter, Mettenleiter, Thomas C., Jardetzky, Theodore S., Longnecker, Richard
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2016
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810733/
https://ncbi.nlm.nih.gov/pubmed/26656711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03032-15
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