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A Single Mutation at PB1 Residue 319 Dramatically Increases the Safety of PR8 Live Attenuated Influenza Vaccine in a Murine Model without Compromising Vaccine Efficacy

The live attenuated influenza vaccine (LAIV) is preferentially recommended for use in most children yet remains unsafe for the groups most at risk. Here we have improved the safety of a mouse-adapted live attenuated influenza vaccine containing the same attenuating amino acid mutations as in human L...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Cox, Andrew, Dewhurst, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810719/
https://ncbi.nlm.nih.gov/pubmed/26676793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02723-15
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