Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway

The cellular response to virus infection is initiated when pathogen recognition receptors (PRR) engage viral pathogen-associated molecular patterns (PAMPs). This process results in induction of downstream signaling pathways that activate the transcription factor interferon regulatory factor 3 (IRF3)...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Pattabhi, Sowmya, Wilkins, Courtney R., Dong, Ran, Knoll, Megan L., Posakony, Jeffrey, Kaiser, Shari, Mire, Chad E., Wang, Myra L., Ireton, Renee C., Geisbert, Thomas W., Bedard, Kristin M., Iadonato, Shawn P., Loo, Yueh-Ming, Gale, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810700/
https://ncbi.nlm.nih.gov/pubmed/26676770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02202-15
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