Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway

The cellular response to virus infection is initiated when pathogen recognition receptors (PRR) engage viral pathogen-associated molecular patterns (PAMPs). This process results in induction of downstream signaling pathways that activate the transcription factor interferon regulatory factor 3 (IRF3)...

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Veröffentlicht in:J Virol
Hauptverfasser: Pattabhi, Sowmya, Wilkins, Courtney R., Dong, Ran, Knoll, Megan L., Posakony, Jeffrey, Kaiser, Shari, Mire, Chad E., Wang, Myra L., Ireton, Renee C., Geisbert, Thomas W., Bedard, Kristin M., Iadonato, Shawn P., Loo, Yueh-Ming, Gale, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810700/
https://ncbi.nlm.nih.gov/pubmed/26676770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02202-15
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