Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway

The cellular response to virus infection is initiated when pathogen recognition receptors (PRR) engage viral pathogen-associated molecular patterns (PAMPs). This process results in induction of downstream signaling pathways that activate the transcription factor interferon regulatory factor 3 (IRF3)...

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Dades bibliogràfiques
Publicat a:J Virol
Autors principals: Pattabhi, Sowmya, Wilkins, Courtney R., Dong, Ran, Knoll, Megan L., Posakony, Jeffrey, Kaiser, Shari, Mire, Chad E., Wang, Myra L., Ireton, Renee C., Geisbert, Thomas W., Bedard, Kristin M., Iadonato, Shawn P., Loo, Yueh-Ming, Gale, Michael
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810700/
https://ncbi.nlm.nih.gov/pubmed/26676770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02202-15
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