Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway

The cellular response to virus infection is initiated when pathogen recognition receptors (PRR) engage viral pathogen-associated molecular patterns (PAMPs). This process results in induction of downstream signaling pathways that activate the transcription factor interferon regulatory factor 3 (IRF3)...

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Bibliografski detalji
Izdano u:J Virol
Glavni autori: Pattabhi, Sowmya, Wilkins, Courtney R., Dong, Ran, Knoll, Megan L., Posakony, Jeffrey, Kaiser, Shari, Mire, Chad E., Wang, Myra L., Ireton, Renee C., Geisbert, Thomas W., Bedard, Kristin M., Iadonato, Shawn P., Loo, Yueh-Ming, Gale, Michael
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2016
Teme:
Vaccines and Antiviral Agents
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810700/
https://ncbi.nlm.nih.gov/pubmed/26676770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02202-15
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