Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C Virus

Hypervariable region 1 (HVR1) (amino acids [aa] 384 to 410) on the E2 glycoprotein of hepatitis C virus contributes to persistent infection by evolving escape mutations that attenuate binding of inhibitory antibodies and by blocking access of broadly neutralizing antibodies to their epitopes. A thir...

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Udgivet i:J Virol
Main Authors: Keck, Zhen-yong, Girard-Blanc, Christine, Wang, Wenyan, Lau, Patrick, Zuiani, Adam, Rey, Felix A., Krey, Thomas, Diamond, Michael S., Foung, Steven K. H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810650/
https://ncbi.nlm.nih.gov/pubmed/26739044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02458-15
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