Hepatitis B Virus Capsids Have Diverse Structural Responses to Small-Molecule Ligands Bound to the Heteroaryldihydropyrimidine Pocket

Though the hepatitis B virus (HBV) core protein is an important participant in many aspects of the viral life cycle, its best-characterized activity is self-assembly into 240-monomer capsids. Small molecules that target core protein (core protein allosteric modulators [CpAMs]) represent a promising...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Virol
Prif Awduron: Venkatakrishnan, Balasubramanian, Katen, Sarah P., Francis, Samson, Chirapu, Srinivas, Finn, M. G., Zlotnick, Adam
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2016
Pynciau:
Structure and Assembly
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810570/
https://ncbi.nlm.nih.gov/pubmed/26842475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03058-15
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