Prime, Shock, and Kill: Priming CD4 T Cells from HIV Patients with a BCL-2 Antagonist before HIV Reactivation Reduces HIV Reservoir Size

Understanding how some HIV-infected cells resist the cytotoxicity of HIV replication is crucial to enabling HIV cure efforts. HIV killing of CD4 T cells that replicate HIV can involve HIV protease-mediated cleavage of procaspase 8 to generate a fragment (Casp8p41) that directly binds and activates t...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Cummins, Nathan W., Sainski, Amy M., Dai, Haiming, Natesampillai, Sekar, Pang, Yuan-Ping, Bren, Gary D., de Araujo Correia, Maria Cristina Miranda, Sampath, Rahul, Rizza, Stacey A., O'Brien, Daniel, Yao, Joseph D., Kaufmann, Scott H., Badley, Andrew D.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2016
Sujets:
Virus-Cell Interactions
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810548/
https://ncbi.nlm.nih.gov/pubmed/26842479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03179-15
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