Pleiotropic consequences of gene knockouts in the phthiocerol dimycocerosate and phenolic glycolipid biosynthetic gene cluster of the opportunistic human pathogen Mycobacterium marinum

Phthiocerol dimycocerosates (PDIMs) and phenolic glycolipids (PGLs) contribute to the pathogenicity of several mycobacteria. Biosynthesis of these virulence factors requires polyketide synthases and other enzymes that represent potential targets for the development of adjuvant antivirulence drugs. W...

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Библиографические подробности
Опубликовано в: :FEMS Microbiol Lett
Главные авторы: Mohandas, Poornima, Budell, William C., Mueller, Emily, Au, Andrew, Bythrow, Glennon V., Quadri, Luis E. N.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2016
Предметы:
Research Letter
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809995/
https://ncbi.nlm.nih.gov/pubmed/26818253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/femsle/fnw016
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