Pleiotropic consequences of gene knockouts in the phthiocerol dimycocerosate and phenolic glycolipid biosynthetic gene cluster of the opportunistic human pathogen Mycobacterium marinum

Phthiocerol dimycocerosates (PDIMs) and phenolic glycolipids (PGLs) contribute to the pathogenicity of several mycobacteria. Biosynthesis of these virulence factors requires polyketide synthases and other enzymes that represent potential targets for the development of adjuvant antivirulence drugs. W...

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Vydáno v:FEMS Microbiol Lett
Hlavní autoři: Mohandas, Poornima, Budell, William C., Mueller, Emily, Au, Andrew, Bythrow, Glennon V., Quadri, Luis E. N.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
Research Letter
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809995/
https://ncbi.nlm.nih.gov/pubmed/26818253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/femsle/fnw016
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