Pleiotropic consequences of gene knockouts in the phthiocerol dimycocerosate and phenolic glycolipid biosynthetic gene cluster of the opportunistic human pathogen Mycobacterium marinum

Phthiocerol dimycocerosates (PDIMs) and phenolic glycolipids (PGLs) contribute to the pathogenicity of several mycobacteria. Biosynthesis of these virulence factors requires polyketide synthases and other enzymes that represent potential targets for the development of adjuvant antivirulence drugs. W...

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Detalhes bibliográficos
Publicado no:FEMS Microbiol Lett
Main Authors: Mohandas, Poornima, Budell, William C., Mueller, Emily, Au, Andrew, Bythrow, Glennon V., Quadri, Luis E. N.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Research Letter
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809995/
https://ncbi.nlm.nih.gov/pubmed/26818253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/femsle/fnw016
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