Pleiotropic consequences of gene knockouts in the phthiocerol dimycocerosate and phenolic glycolipid biosynthetic gene cluster of the opportunistic human pathogen Mycobacterium marinum

Phthiocerol dimycocerosates (PDIMs) and phenolic glycolipids (PGLs) contribute to the pathogenicity of several mycobacteria. Biosynthesis of these virulence factors requires polyketide synthases and other enzymes that represent potential targets for the development of adjuvant antivirulence drugs. W...

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Detalles Bibliográficos
Publicado en:FEMS Microbiol Lett
Autores principales: Mohandas, Poornima, Budell, William C., Mueller, Emily, Au, Andrew, Bythrow, Glennon V., Quadri, Luis E. N.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2016
Materias:
Research Letter
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809995/
https://ncbi.nlm.nih.gov/pubmed/26818253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/femsle/fnw016
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