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Tandem Repeat Hypothesis in Imprinting: Deletion of a Conserved Direct Repeat Element Upstream of H19 Has No Effect on Imprinting in the Igf2-H19 Region

Igf2 and H19 are reciprocally imprinted genes on mouse distal chromosome 7. They share several regulatory elements, including a differentially methylated region (DMR) upstream of H19 that is paternally methylated throughout development. The cis-acting sequence requirements for targeting DNA methylat...

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Autors principals: Lewis, Annabelle, Mitsuya, Kohzoh, Constancia, Miguel, Reik, Wolf
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC480907/
https://ncbi.nlm.nih.gov/pubmed/15199123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.13.5650-5656.2004
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