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An upstream repressor element plays a role in Igf2 imprinting

The imprinted Igf2 gene is associated with a small upstream region that is differentially methylated on the active paternal allele. We have identified a repressor element within this sequence and shown that repression is probably mediated through a trans- acting factor, GCF2. DNA methylation of this...

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Udgivet i:EMBO J
Principais autores: Eden, Sharon, Constancia, Miguel, Hashimshony, Tamar, Dean, Wendy, Goldstein, Beth, Johnson, Alfred C., Keshet, Ilana, Reik, Wolf, Cedar, Howard
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125515/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11432838/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.13.3518
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