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Nonsense Mutations in the Rhodopsin Gene that Give Rise to Mild Phenotypes Trigger mRNA Degradation in Human Cells by Nonsense-Mediated Decay
Eight different nonsense mutations in the human rhodopsin gene cause retinitis pigmentosa (RP), an inherited degenerative disease of the retina that can lead to complete blindness. Although all these nonsense mutations lead to premature termination codons (PTCs) in rhodopsin mRNA, some display domin...
Gardado en:
| Publicado en: | Exp Eye Res |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4808503/ https://ncbi.nlm.nih.gov/pubmed/26416182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2015.09.013 |
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