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Synthesis and in vitro anticancer evaluation of some 4,6-diamino-1,3,5-triazine-2-carbohydrazides as Rad6 ubiquitin conjugating enzyme inhibitors

Series of 4-amino-6-(arylamino)-1,3,5-triazine-2-carbohydrazides (3a–e) and N′-phenyl-4,6-bis(arylamino)-1,3,5-triazine-2-carbohydrazides (6a–e), for ease of readership, we will abbreviate our compound names as “ new triazines”, have been synthesized, based on the previously reported Rad6B-inhibitor...

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Podrobná bibliografie
Vydáno v:Bioorg Med Chem Lett
Hlavní autoři: Kothayer, Hend, Spencer, Sebastian M., Tripathi, Kaushlendra, Westwell, Andrew D., Palle, Komaraiah
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808444/
https://ncbi.nlm.nih.gov/pubmed/26965855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.02.085
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