Insights into the substrate specificity of the MutT pyrophosphohydrolase using structural analogues of 8-oxo-2′-deoxyguanosine nucleotide

The bacterial repair enzyme MutT hydrolyzes the damaged nucleotide OdGTP (the 5′-triphosphate derivative of 8-oxo-2′-deoxyguanosine; OdG), which is a known mutagen and has been linked to antibacterial action. Previous work has indicated important roles for the C8-oxygen, N7-hydrogen, and C2-exocycli...

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Published in:Bioorg Med Chem Lett
Main Authors: Hamm, Michelle L., McFadden, Emily J., Ghio, Michael, Lindell, Maria A. M., Gerien, Kenneth S., O’Handley, Suzanne F.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808366/
https://ncbi.nlm.nih.gov/pubmed/26965860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.02.083
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