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Insights into the substrate specificity of the MutT pyrophosphohydrolase using structural analogues of 8-oxo-2′-deoxyguanosine nucleotide
The bacterial repair enzyme MutT hydrolyzes the damaged nucleotide OdGTP (the 5′-triphosphate derivative of 8-oxo-2′-deoxyguanosine; OdG), which is a known mutagen and has been linked to antibacterial action. Previous work has indicated important roles for the C8-oxygen, N7-hydrogen, and C2-exocycli...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4808366/ https://ncbi.nlm.nih.gov/pubmed/26965860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.02.083 |
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